The port city of Hai Phong is the third largest city in Vietnam. It has been experiencing fast economic growth for the last few decades. However, this growth has been posing serious water resource challenges in terms of water pollution. Furthermore, climate change impacts like sea level rise and changes in rainfall and river flow patterns threaten to exacerbate these problems. This study aims at identifying the current and future interrelationships between water availability from a freshwater river system and the growing water demands from industry, agriculture and urban sectors in the context of climate change and water pollution. A theoretical framework for this study is initially being developed to clarify the effects of climate change and water pollution on current and future trends that would impede sustainable water supply of fresh water river system for the anticipated growth demands for domestic, agricultural and industrial uses. These effects will be analyzed by coupling dynamic hydrological and Decision Bayesian Network models. These decision support tools will be used to initiate the most plausible options for adaptation actions that could be used to improve and maintain water resource system reliability despise the increased stresses from climate change, water pollution and population growth. The proposed theoretical framework will be improved through comprehensive and professional advice from researchers participating in the NCCARF conference with a view to developing a feasible and robust academic research project which will contribute to the development of collective and decisive adaptation actions for water resource management in Hai Phong.